Interstate 20 is a major east–west Interstate Highway in the Southern United States. I‑20 runs 1,535 miles beginning near Kent, Texas, at I-10 to Florence, South Carolina, at I-95. Between Texas and South Carolina, I‑20 runs through northern Louisiana, central Mississippi, western and north-central Alabama, and north-central Georgia. The major cities that I-20 connects to includes (from west to east) Fort Worth; Dallas; Shreveport, Louisiana; Jackson, Mississippi; Birmingham, Alabama; Atlanta; and Columbia, South Carolina. I‑20 also intersects seven of the ten primary north–south Interstates (all except I‑5, I‑15, and I‑25) and also the east–west Interstates 10 and 30.
From its terminus at I‑95, the highway continues about 2 miles eastward into the city of Florence as Business Spur 20.